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Vitamin D Activation Pdf Free

Vitamin D Activation Pdf Free

 

Vitamin D Activation Pdf Free -- http://shurll.com/bmmjx

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Perwad,,et,,al.,,J,,Bone,,Miner,,Res19,,:429,,435,2004,,CrossRefMedline,,,,Perwad,,F,,,Zhang,,MY,,,Tenenhouse,,HS,,,Portale,,AA:,,Fibroblast,,growth,,factor,,23,,impairs,,phosphorus,,and,,vitamin,,D,,metabolism,,in,,vivo,,and,,suppresses,,25-hydroxyvitamin,,D-1alpha-hydroxylase,,expression,,in,,vitro.,,Vitamin,,,D,,,,as,,,either,,,D3,,,or,,,D2,,,,does,,,not,,,have,,,significant,,,biologic,,,activity,,,and,,,must,,,be,,,metabolized,,,within,,,the,,,body,,,to,,,the,,,hormonally,,,active,,,form,,,1,25,,,dihydroxyvitamin,,,D.,,,Louis,,,,MO,,,63110.,,,J,Intern,Med244,:121,131,1998,CrossRefMedline,,Coburn,JW,,Maung,HM,,Elangovan,L,,Germain,MJ,,Lindberg,JS,,Sprague,SM,,Williams,ME,,Bishop,CW:,Doxercalciferol,safely,suppresses,PTH,levels,in,patients,with,secondary,hyperparathyroidism,associated,with,chronic,kidney,disease,stages,3,and,4.,(9),also,showed,that,FGF-23,induced,a,dosage-dependent,decrease,in,1--hydroxylase,mRNA.,

 

The,role,of,this,extrarenal,1--hydroxylase,,with,the,production,of,1,25-dihydroxyvitamin,D,in,these,tissues,,is,not,well,understood,,but,a,variety,of,in,vitro,studies,indicate,that,this,process,may,be,involved,in,the,regulation,of,cell,growth,and,differentiation,(1).,Previous,,SectionNext,,Section,,Conclusions,,In-depth,,research,,in,,the,,past,,two,,decades,,has,,uncovered,,many,,of,,the,,potential,,mechanisms,,in,,which,,vitamin,,D,,is,,involved,,in,,the,,initiation,,and,,maintenance,,of,,the,,disturbances,,of,,bone,,and,,mineral,,metabolism,,in,,the,,CKD,,population.,,The,,,importance,,,of,,,the,,,abnormal,,,vitamin,,,D,,,metabolism,,,is,,,being,,,investigated,,,vigorously,,,in,,,view,,,of,,,the,,,observations,,,that,,,vitamin,,,D,,,may,,,have,,,important,,,biologic,,,actions,,,in,,,many,,,tissues,,,in,,,addition,,,to,,,bone,,,and,,,parathyroid.,,,Martin,Division,of,Nephrology,,Saint,Louis,University,,St.,Shimada,,et,,al.,,

 

Am,J,Nephrol27,:36,43,2007,CrossRefMedline,,Chandra,P,,Binongo,JN,,Ziegler,TR,,Schlanger,LE,,Wang,W,,Someren,JT,,Tangpricha,V:,Cholecalciferol,(vitamin,D3),therapy,and,vitamin,D,insufficiency,in,patients,with,chronic,kidney,disease:,A,randomized,controlled,pilot,study.,This,,,has,,,been,,,reproduced,,,in,,,bench,,,and,,,bedside,,,clinical,,,observations.,,,Kidney,Int63,:1483,1490,2003,CrossRefMedline,,Wolf,M,,Shah,A,,Gutierrez,O,,Ankers,E,,Monroy,M,,Tamez,H,,Steele,D,,Chang,Y,,Camargo,CA,Jr,,Tonelli,M,,Thadhani,R:,Vitamin,D,levels,and,early,mortality,among,incident,hemodialysis,patients.,Am,,,J,,,Pathol155,,,:1361,,,1370,1999,,,CrossRefMedline,,,,,,Nykjaer,,,A,,,,Dragun,,,D,,,,Walther,,,D,,,,Vorum,,,H,,,,Jacobsen,,,C,,,,Herz,,,J,,,,Melsen,,,F,,,,Christensen,,,EI,,,,Willnow,,,TE:,,,An,,,endocytic,,,pathway,,,essential,,,for,,,renal,,,uptake,,,and,,,activation,,,of,,,the,,,steroid,,,25-(OH),,,vitamin,,,D3.,,,Am,J,Kidney,Dis50,:59,68,2007,CrossRefMedline,,Teng,M,,Wolf,M,,Ofsthun,MN,,Lazarus,JM,,Hernan,MA,,Camargo,CA,Jr,,Thadhani,R:,Activated,injectable,vitamin,D,and,hemodialysis,survival:,A,historical,cohort,study.,Recent,,,observations,,,have,,,indicated,,,that,,,chronic,,,kidney,,,disease,,,seems,,,to,,,be,,,associated,,,with,,,a,,,high,,,incidence,,,of,,,nutritional,,,vitamin,,,D,,,insufficiency,,,or,,,deficiency,,,as,,,manifested,,,by,,,decreased,,,levels,,,of,,,25-hydroxyvitamin,,,D.,,,The,,,importance,,,of,,,a,,,declining,,,GFR,,,in,,,limiting,,,the,,,ability,,,of,,,the,,,kidney,,,to,,,produce,,,1,,,to,,,25-dihydroxyvitamin,,,D,,,was,,,illustrated,,,by,,,the,,,work,,,of,,,Nykjaer,,,et,,,al.,,,Next,,Section,,Abstract,,Abnormalities,,in,,vitamin,,D,,metabolism,,play,,a,,major,,role,,in,,the,,pathogenesis,,of,,secondary,,hyperparathyroidism,,in,,chronic,,kidney,,disease.,,Proc,Natl,Acad,Sci,U,S,A98,:13895,13900,2001,Abstract/FREE,Full,Text,Leheste,JR,,Rolinski,B,,Vorum,H,,Hilpert,J,,Nykjaer,A,,Jacobsen,C,,Aucouturier,P,,Moskaug,JO,,Otto,A,,Christensen,EI,,Willnow,TE:,Megalin,knockout,mice,as,an,animal,model,of,low,molecular,weight,proteinuria., 4bc16de163

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